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SELECTED PUBLICATIONS

  •  Rahul Pasupureddy, Sonia Verma, Bharti Goyal, Akansha Pant, Ruby Sharma, Shruti Bhatt,Kapil Vashisht , Shailja Singh, Ajay K. Saxena, Rajnikant Dixit, Soumyananda Chakraborti*,  Kailash C. Pandey* (2024). Understanding the complex formation of falstatin; an  endogenous macromolecular inhibitor of falcipains. International Journal of Biological Macromolecules, doi: 10.1016/j.ijbiomac.2024.130420

  • Harit R, De S, Singh PK, Kashyap D, Kumar M, Sahu D, Yadav CP, Mohan M, Singh V, Tomar RS, Pandey KC*, Vashisht K* (2024). Association of the C allele of rs479200 in the EGLN1 gene with COVID-19 severity in Indian population: a novel finding. Hum Genomics. 2024 Feb 8;18(1):17. doi: 10.1186/s40246-024-00584-x

  • Atul#, Chaudhary P#, Gupta S, Shoaib R, Pasupureddy R, Goyal B, Kumar B, Singh OP, Dixit R, Singh S, AkhterM, KapoorN, PandeV, Chakraborti S, Vashisht K*, Pandey KC*  (2023). Artemisinin resistance in P. falciparum: probing the interacting partners of Kelch13 protein in parasite. Journal of Global Antimicrobial Resistance. 2023 Aug 24;35:67-75. doi: 10.1016

  • Pradhan S, Hore S, Roy S, Manna S, Dam P, Mondal R, Ghati A, Biswas T, Shaw S, Sharma S, Singh WS, Maji SK, Roy S, Basu A, Pandey KC, Samanta S, Vashisht K, Dolai TK, Kundu PK, Mitra S, Biswas D, Sadat A, Shokriyan M, Maity AB, Mandal AK, İnce İA (2023). Geo-environmental factors and the effectiveness of mulberry leaf extract in managing malaria. Scientific Report, PMC10491663 DOI: 10.1038/s41598-023-41668-3

  • Kumar S, Pant M, Prashar C, Pandey KC, Roy S, Pande V, Dandapat A (2024). Myco-synthesis of multi-twinned silver nanoparticles as potential antibacterial and antimalarial agents. Royal Society of Chemistry Advance. Jan 2;14(2):1114-1122. doi: 10.1039/d3ra07752g

  • Das R*, Vashisht K and Pandey KC (2023). A novel multiplex qPCR assay for clinical diagnosis of non-human malaria parasites-Plasmodium knowlesi and Plasmodium cynomolgi. Front. Vet. Sci. 10:1127273. doi: 10.3389/fvets.2023.1127273

  • Recognition of fold- and function-specific sites in the ligand-binding domain of the thyroid hormone receptor-like family. Verma S, Chakraborti S, Singh OP, Pande V, Dixit R, Pandey AV, Pandey KC*. Front Endocrinol. 2022 Sep 29;13:981090. doi: 10.3389/fendo.2022.981090. eCollection 2022

  • A comprehensive overview of the existing microbial symbionts in mosquito vectors: An important tool for impairing patpathogen transmission. Vandana V*, Kona MP, Kumar J, Singh OP, Pandey KC*. Exp Parasitol. 2022 Oct 29;243:108407. doi: 10.1016/j.exppara.2022.108407

  • Kapil Vashisht#, Sukrit Srivastava#, Vandana, Ram Das, Supriya Sharma, Nitin Bhardwaj, Anupkumar R Anvikar, Tong-Soo Kim, Byoung-Kuk Na, Ho-Joon Shin, Kailash C Pandey* (2021). Cyclic constrained immunoreactive peptides from crucial P. falciparum proteins: potential implications in malaria diagnostics.  Translational Research., 2022 Jun 10:S1931-5244(22)00140-2. doi: 10.1016/j.trsl.2022.06.008

  • Chaudhary, P., Gupta, S., Shoaib, R., Pasupureddy, R., Goyal, B., Kumar, B., ... & Pandey, K. C. (2023). Artemisinin resistance in P. falciparum: Probing the interacting partners of Kelch13 protein in parasite. Journal of Global Antimicrobial Resistance.

  • Pandey, K., Kumari, V., Prasad, K., Kalia, I. K., Sindhu, G., Dixit, R., ... & Singh, A. (2023). ROLE OF METACASPASE IN MALARIA TRANSMISSION BIOLOGY. International Journal of Infectious Diseases, 130, S54.

  • Kumar, J., Prasad, K., Kumari, V., & Pandey, K. (2023). AN ESTERASE-LIKE PROTEIN (ELP) CONFERRED MALATHION AND DELTAMETHRIN RESISTANCE IN THE INDIAN FIELD POPULATION OF ANOPHELES STEPHENSI. International Journal of Infectious Diseases, 130, S33-S34.

  • Vashisht, K., Prashar, C., Tyagi, S., Rawat, G., Kumari, P., & Pandey, K. C. (2020). Are aptamers really promising for diagnostic or therapeutic applications in dengue?. Dengue, 41, 31.

  • Srivastava, S., Verma, S., Kamthania, M., Saxena, A. K., Pandey, K. C., Pande, V., & Kolbe, M. (2023). Exploring the structural basis to develop efficient multi-epitope vaccines displaying interaction with HLA and TAP and TLR3 molecules to prevent NIPAH infection, a global threat to human health. Plos one, 18(3), e0282580.

  • Vashisht, K., Goyal, B., Pasupureddy, R., Na, B. K., Shin, H. J., Sahu, D., ... & Joon-Shin, H. (2023). Exploring the Immunodominant Epitopes of SARS-CoV-2 Nucleocapsid Protein as Exposure Biomarker. Cureus, 15(2).

  • Prashar, Cherish, et al. "The landscape of nature-derived antimalarials-potential of marine natural products in countering the evolving Plasmodium." Frontiers in Drug Discovery 2 (2022): 1065231.

  • Vandana, Prasad KM, Kalia M, Sindhu G, Dixit R, Rawat DS, Singh OP, Singh AP, Pandey KC (2022). Dissecting The role of Plasmodium metacaspase-2 in malaria gametogenesis and sporogony, Emerg. Microbes Infect., 11:1, 938-955, doi: 10.1080/22221751.2022.2052357

  • Vashisht K#, Srivastava S#, Vandana, Das R, Sharma S, Bhardwaj N, Anvikar A, Kim TS, Na BK, Shin HJ, Pandey KC (2021). Cyclic constrained immunoreactive peptides from crucial P. falciparum proteins: potential implications in malaria diagnostics. Translational Research., 2022 Jun 10:S1931-5244(22)00140-2. doi: 10.1016/j.trsl.2022.06.008

  • Vandana, Rajan Pandey, E Srinivasan, Inderjeet Kalia, Agam P Singh, Ajay Saxena, R Rajaekaran, Dinesh Gupta, Kailash C Pandey (2021). Plasmodium falciparum metacaspase-2 capture its natural substrate in a non-canonical way, J. Biochem., 170(5), 639–653, doi: 10.1093/jb/mvab086

 

  • Vandana, Shankar S, Prasad KM, Kashif M, Kalia I, Rai R, Singh AP, Pandey KC* (2020). A nonpeptidyl molecule modulates apoptosis-like cell death by inhibiting P. falciparum metacapase-2, Biochem J., 7;477(7):1323-1344. doi: 10.1042.

 

  • Sukrit Srivastava,, Sonia Verma, Mohit Kamthania, Rupinder Kaur, Ruchi Kiran Badyal, Ajay Kumar Saxena, Ho-Joon Shin, Michael Kolbe, Kailash C Pandey (2020). Structural Basis for Designing Multiepitope Vaccines Against COVID-19 Infection: In Silico Vaccine Design and Validation. JMIR Bioinform Biotech. 2020;1(1):e19371. doi:10.2196/19371.

 

  • Vandana, Dixit R, Tiwari R, Katyal A, Pandey KC*.Metacaspases: Potential Drug Target Against Protozoan Parasites (2019). Front Pharmacol., 18;10:790.Kumar B, Verma S, Kashif M, Sharma R, Atul, Dixit R, Singh AP, Pande V, Saxena AK, Abid M, Pandey KC*. Metacaspase-3 of Plasmodium falciparum: An atypical trypsin-like serine protease (2019). Int J Biol Macromol., 1;138:309-320.

 

  • Pasupureddy R, Verma S, Pant A, Sharma R, Seshadri S, Pande V, Saxena AK, Dixit R, Pandey KC*. Crucial residues in falcipains that mediate hemoglobin hydrolysis (2019). Exp Parasitol. Jan 12;197:43-50. doi: 10.1016/j.exppara.2019.01.005.

 

  • Pant A, Kumar R, Wani NA, Verma S, Sharma S, Sharma R, Pande V, Saxena AK, Dixit R, Rai R, Pandey KC* (2018). Allosteric Site Inhibitor Disrupting Auto-processing of Malarial Cysteine Proteases. Scientific Reports, 8;16193.

 

  • Pasupureddy R, Atul, Seshadri S, Pande V, Dixit R, Pandey KC*. Current scenario and future strategies to fight artemisinin resistance (2018). Parasitol Res. Jan;118(1):29-42. doi: 10.1007/s00436-018-6126-x. 

 

  • Vandana, Agam Prasad Singh, Jitendra Singh, Ruby Sharma, Mymoona Akhter, Ajay Saxena 4 , Brijesh Rathi, Anju Katyal 5 , Rajnikant Dixit, Kailash C Pandey* (2018). Metacaspase-2 (MCA-2): Functional characterization of potential modulator of programme cell death in P. falciparum, Mol. Biochem. Parasitol, 220, 28-41.

 

  • Singh S, Rajendran V, He J, Singh AK, Achieng AO, Kumari V, Pant A, Nasamu AS, Pandit M, Singh J, Quadiri A, Gupta N, Singh P, Ghosh PC, Singh BK, Narayanan L, Kempaiah P, Chandra R, Dunn BM, Pandey KC, Goldberg DE, Singh AP, Rathi B (2018). Fast-acting small molecules targeting malarial aspartyl proteases, plasmepsins, inhibit malaria infection at multiple life stages. ACS Infect Dis. doi: 10.1021/acsinfecdis.8b00197.

 

  • Pant A, Pasupureddy R, Pande V, Seshadri S, Dixit R, Pandey KC * (2017). Proteases in Mosquito Borne Diseases: New Avenues in Drug Development. Curr Top Med Chem. 17(19):2221-2232.

 

  • Kapil Vashisht, Sonia Verma, Sunita Gupta, Andrew M Lynn, Rajnikant Dixit, Neelima Mishra, Neena Valecha, Karleigh A. Hamblin, Robin Maytum*, Kailash C Pandey*, and Mark van der Giezen* (2017). Engineering nucleotide specificity for Succinyl-CoA Synthetase of Blastocystis: The Emerging Role of Gatekeeper Residues. Biochemistry, 56, 334-542.

 

  • Verma S, Dixit R, Pandey KC* (2016) Cysteine Proteases; Mode of Activation and future Prospect as Pharmacological Targets. Front. Pharmacol. 25;7:107. doi: 10.3389.

 

  • Srinivasan Sundararaj, Ajay K. Saxena, Kapil Vashisht, Supriya Sharma, Anup Anvikar, Rajnikant Dixit, Philip J Rosenthal, Kailash C. Pandey*  (2014). Cross-Talk between Malarial Cysteine Proteases and Falstatin: The BC Loop as a Hot-Spot Target. PLoS One 9(4), e93 008. Doi:10.1371

 

  • Srinivasan Sundararaj, Deepak Singh, Ajay Saxena, Kapil Vashisht, Puran Sijwali, Rajnikant Dixit, Kailash C. Pandey* (2012). The Ionic and Hydrophobic Interactions are required for the Auto Activation of Cysteine Proteases of Plasmodium falciparum. PLoS One 7(10): e47227. doi:10.1371.

 

  • Pandey KC, Singh N, Kapur SA, Bogyo M, Rosenthal PJ (2006). Falstatin, a Cysteine Protease Inhibitor of  Plasmodium falciparum, facilitates Erythrocyte Invasion. PLoS Pathogens.; 2: e117.

 

  • Pandey KC, Wang SX, Sijwali PS, Lau AL, Mckerrow JH, Rosenthal PJ (2005). The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif. PNAS; 102: 9138-9143.

  • Wang SX, Pandey KC, Somoza JR, Brinen LS, Sijwali PS, Kortemme T, Rosenthal PJ, Mckerrow JH (2006). Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. PNAS; 103:11503-11508.

 

  • Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK et al. (2007), The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure.;15(5):535-43.

 

  • Pandey KC, Sijwali PS, Singh A, Na BK, Rosenthal PJ (2004). Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2. J Biol Chem.; 279:348-3491.

 

  • Pandey KC, Singh S, Pattnaik P, Pillai CR, Pillai U, Lynn A, Jain SK, Chitnis CE (2002). Bacterially expressed and refolded receptor binding domain of Plasmodium falciparum EBA-175 elicits invasion inhibitory antibodies. Mol Biochem Parasitol.; 123:23-33.

 

  • Singh S, Pandey KC, Chattopadhayay R, Yazdani SS, Lynn A, Bharadwaj A, Ranjan A, Chitnis CE (2001). Biochemical, biophysical, and functional characterization of bacterially expressed and refolded receptor binding domain of Plasmodium vivax duffy-binding protein. J  Biol Chem., 6:17111-17116.

INTERNATIONAL PATENT

  • Invention of a method for polypeptide renaturation (erythrocyte binding protein of P. vivax and P. falciparum). European Patent Code: C07K14/445; and International Patent Code: C07K14/195.  Inventors: Chetan E Chitnis., Kailash C Pandey., Singh S., Yazdani S., Pattnaik P., Date; 14 Feb. 2002.

BOOK CHAPTERS

  • Pasupureddy R, Seshadri S, Dixit R and Pandey K.C. (2019). Protein-Protein Interactions in Malaria: Emerging Arena for Future Chemotherapeutics; Parasitology and Microbiology Research, IntechOpen, DOI: 10.5772/intechopen.89217.

  • Cysteine Proteases of Human Malaria Parasites by Kailash C Pandey; “Role of proteases in cellular dysfunction” volume 7, DOI 10.1007/978-14614-9233-7, page 121-134, edited by Dhalla N and Chakraborti S, Publisher Springer Science and Business Media New York, 2013.

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